Computational Structural & Systems Biology
Home Yu Xia People Papers Courses Resources Jobs
Yu Xia's photo

Yu (Brandon) Xia

Department of Bioengineering
McGill University
3480 University Street
Montreal, Quebec H3A 0E9, Canada

Email: brandon.xia@mcgill.ca
Office: McConnell Engineering Building, Room 360
Phone: 514-398-5026 (O), 514-246-8751 (C)

BIOGRAPHY

I am a Professor of Bioengineering at McGill University, where I hold the Canada Research Chair in Computational and Systems Biology. At McGill, I am also affiliated with the Graduate Program in Biological and Biomedical Engineering, the Graduate Program in Quantitative Life Sciences, the Quantitative Biology Initiative, the Centre for Structural Biology, and the Department of Biomedical Engineering. External to McGill, I am affiliated with the Center for Cancer Systems Biology at Dana-Farber Cancer Institute.

I graduated from Peking University in 1995 with B.S. in Chemistry (major) and Computer Science (minor). I received my Ph.D. in Chemistry from Stanford University in 2003, specializing in computational biology with Michael Levitt (2013 Nobel laureate). After postdoctoral research with Mark Gerstein at Yale University, I became an Assistant Professor of Bioinformatics, Chemistry, and Biomedical Engineering at Boston University. I joined McGill in 2013 as Associate Professor and was promoted to Professor in 2018.

Here is my Google Scholar profile.

SELECTED PAPERS

  1. Nature of long-range evolutionary constraint in enzymes: insights from comparison to pseudoenzymes with similar structures. Mol. Biol. Evol. 35: 2597-2606 (2018).
  2. Interactome evolution: insights from genome-wide analyses of protein-protein interactions. Curr. Opin. Struct. Biol. 50: 42-48 (2018).
  3. Widespread expansion of protein interaction capabilities by alternative splicing. Cell 164: 805-817 (2016).
  4. Widespread macromolecular interaction perturbations in human genetic disorders. Cell 161: 647-660 (2015).
  5. Signatures of pleiotropy, economy and convergent evolution in a domain-resolved map of human-virus protein-protein interaction networks. PLoS Pathog. 9: e1003778 (2013).
  6. Structural principles within the human-virus protein-protein interaction network. Proc. Natl. Acad. Sci. USA 108: 10538-10543 (2011).
  7. Structural determinants of protein evolution are context-sensitive at the residue level. Mol. Biol. Evol. 26: 2387-2395 (2009).
  8. Relating three-dimensional structures to protein networks provides evolutionary insights. Science 314: 1938-1941 (2006).
  9. Roles of mutation and recombination in the evolution of protein thermodynamics. Proc. Natl. Acad. Sci. USA 99: 10382-10387 (2002).
  10. Ab initio construction of protein tertiary structures using a hierarchical approach. J. Mol. Biol. 300: 171-185 (2000).
spacer
rule

Yu (Brandon) Xia Lab  |  Department of Bioengineering  |  McGill University