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Yu Xia's photo Yu (Brandon) Xia

Department of Bioengineering
McGill University
3480 University Street
Montreal, Quebec H3A 0E9, Canada

Office: McConnell Engineering Building, Room 360
Phone: 514-398-5026


I am a Professor of Bioengineering at McGill University, where I hold the Canada Research Chair in Computational and Systems Biology. At McGill, I am also affiliated with the Graduate Program in Biological and Biomedical Engineering, the Graduate Program in Quantitative Life Sciences, the Center for Structural Biology, the Centre for Applied Mathematics in Bioscience and Medicine, and the Department of Biomedical Engineering. External to McGill, I am affiliated with the Center for Cancer Systems Biology at Dana-Farber Cancer Institute.

I graduated from Peking University in 1995 with B.S. in Chemistry (major) and Computer Science (minor). I received my Ph.D. in Chemistry from Stanford University in 2003, specializing in computational biology with Michael Levitt. After postdoctoral research with Mark Gerstein at Yale University, I became an Assistant Professor of Bioinformatics, Chemistry, and Biomedical Engineering (secondary) at Boston University. I joined McGill University in 2013 as Associate Professor and was promoted to Professor in 2018.

Explore my Google Scholar profile, ORCID profile, and academic genealogy.

  1. Sharir-Ivry A, Xia Y. Quantifying evolutionary importance of protein sites: a tale of two measures. PLOS Genet. 17: e1009476 (2021).
  2. Ghadie MA, Xia Y. Estimating dispensable content in the human interactome. Nat. Commun. 10: 3205 (2019).
  3. Sharir-Ivry A, Xia Y. Nature of long-range evolutionary constraint in enzymes: insights from comparison to pseudoenzymes with similar structures. Mol. Biol. Evol. 35: 2597-2606 (2018).
  4. Gahdie MA, Coulombe-Huntington J, Xia Y. Interactome evolution: insights from genome-wide analyses of protein-protein interactions. Curr. Opin. Struct. Biol. 50: 42-48 (2018).
  5. Ghadie MA, Lambourne L, Vidal M, Xia Y. Domain-based prediction of the human isoform interactome provides insights into the functional impact of alternative splicing. PLOS Comput. Biol. 13: e1005717 (2017).
  6. Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, et al. Widespread expansion of protein interaction capabilities by alternative splicing. Cell 164: 805-817 (2016).
  7. Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, et al. Widespread macromolecular interaction perturbations in human genetic disorders. Cell 161: 647-660 (2015).
  8. Garamszegi S, Franzosa EA, Xia Y. Signatures of pleiotropy, economy and convergent evolution in a domain-resolved map of human-virus protein-protein interaction networks. PLOS Pathog. 9: e1003778 (2013).
  9. Franzosa EA, Xia Y. Structural principles within the human-virus protein-protein interaction network. Proc. Natl. Acad. Sci. USA 108: 10538-10543 (2011).
  10. Wang Y, Zhang XS, Xia Y. Predicting eukaryotic transcriptional cooperativity by Bayesian network integration of genome-wide data. Nucleic Acids Res. 37: 5943-5958 (2009).
  11. Franzosa EA, Xia Y. Structural determinants of protein evolution are context-sensitive at the residue level. Mol. Biol. Evol. 26: 2387-2395 (2009).
  12. Kim PM, Lu LJ, Xia Y, Gerstein MB. Relating three-dimensional structures to protein networks provides evolutionary insights. Science 314: 1938-1941 (2006).
  13. Xia Y, Levitt M. Roles of mutation and recombination in the evolution of protein thermodynamics. Proc. Natl. Acad. Sci. USA 99: 10382-10387 (2002).
  14. Xia Y, Huang ES, Levitt M, Samudrala R. Ab initio construction of protein tertiary structures using a hierarchical approach. J. Mol. Biol. 300: 171-185 (2000).

Yu (Brandon) Xia Lab  |  Department of Bioengineering  |  McGill University