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Yu (Brandon) Xia

Department of Bioengineering
Faculty of Engineering
McGill University
Montreal, Quebec H3A 0C3, Canada

Office: Macdonald Engineering Building, Room 389
Phone: 514-398-5026 (O), 514-246-8751 (C)


I am an Associate Professor in the Department of Bioengineering at McGill University, where I hold a Canada Research Chair in Computational and Systems Biology. At McGill, I am also affiliated with the Quantitative Biology Initiative, the Centre for Structural Biology, and the Department of Biomedical Engineering. External to McGill, I am affiliated with the Bioinformatics Program at Boston University, and the Center for Cancer Systems Biology at Dana-Farber Cancer Institute.

I graduated from Peking University with B.S. in Chemistry (major) and Computer Science (minor). I received my Ph.D. in Chemistry from Stanford University specializing in computational structural biology with Michael Levitt (2013 Nobel laureate), and carried out postdoctoral research in bioinformatics with Mark Gerstein at Yale University. Prior to joining McGill University, I was an Assistant Professor of Bioinformatics and Chemistry at Boston University, with a secondary appointment in Biomedical Engineering.

Here is my Google Scholar profile.


  1. The impact of native state switching on protein sequence evolution. Mol. Biol. Evol. In press (2017).
  2. Widespread expansion of protein interaction capabilities by alternative splicing. Cell 164: 805-817 (2016).
  3. Widespread macromolecular interaction perturbations in human genetic disorders. Cell 161: 647-660 (2015).
  4. Signatures of pleiotropy, economy and convergent evolution in a domain-resolved map of human-virus protein-protein interaction networks. PLoS Pathog. 9: e1003778 (2013).
  5. Consequences of domain insertion on sequence-structure divergence in a superfold. Proc. Natl. Acad. Sci. USA 110: E3381-E3387 (2013).
  6. Quantitative residue-level structure-evolution relationships in the yeast membrane proteome. Genome Biol. Evol. 5: 734-744 (2013).
  7. Active clustering of biological sequences. J. Mach. Learn. Res. 13: 203-225 (2012).
  8. Structural principles within the human-virus protein-protein interaction network. Proc. Natl. Acad. Sci. USA 108: 10538-10543 (2011).
  9. Protein evolution in yeast transcription factor subnetworks. Nucleic Acids Res. 38: 5959-5969 (2010).
  10. Predicting eukaryotic transcriptional cooperativity by Bayesian network integration of genome-wide data. Nucleic Acids Res. 37: 5943-5958 (2009).
  11. Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network. Genome Biol. 10: R91 (2009).
  12. Structural determinants of protein evolution are context-sensitive at the residue level. Mol. Biol. Evol. 26: 2387-2395 (2009).
  13. Relating three-dimensional structures to protein networks provides evolutionary insights. Science 314: 1938-1941 (2006).
  14. Roles of mutation and recombination in the evolution of protein thermodynamics. Proc. Natl. Acad. Sci. USA 99: 10382-10387 (2002).
  15. Ab initio construction of protein tertiary structures using a hierarchical approach. J. Mol. Biol. 300: 171-185 (2000).

Yu (Brandon) Xia Lab  |  Department of Bioengineering  |  McGill University