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Yu (Brandon) Xia

Department of Bioengineering
McGill University
3480 University Street
Montreal, Quebec H3A 0E9, Canada

Email: brandon.xia@mcgill.ca
Office: McConnell Engineering Building, Room 360
Phone: 514-398-5026

BIOGRAPHY

I am a Professor of Bioengineering at McGill University, where I hold the Canada Research Chair in Computational and Systems Biology. At McGill, I am also affiliated with the Graduate Program in Biological and Biomedical Engineering, the Graduate Program in Quantitative Life Sciences, the Centre for Structural Biology, and the Department of Biomedical Engineering. External to McGill, I am affiliated with the Center for Cancer Systems Biology at Dana-Farber Cancer Institute.

I graduated from Peking University in 1995 with B.S. in Chemistry (major) and Computer Science (minor). I received my Ph.D. in Chemistry from Stanford University in 2003, specializing in computational biology with Michael Levitt. After postdoctoral research with Mark Gerstein at Yale University, I became an Assistant Professor of Bioinformatics and Chemistry at Boston University in 2006. I joined McGill University in 2013 as Associate Professor and was promoted to Professor in 2018.

Explore my Google Scholar profile, ORCID profile, and academic genealogy.

SELECTED PAPERS

  1. Estimating dispensable content in the human interactome. Nat. Commun. 10: 3205 (2019).
  2. Nature of long-range evolutionary constraint in enzymes: insights from comparison to pseudoenzymes with similar structures. Mol. Biol. Evol. 35: 2597-2606 (2018).
  3. Interactome evolution: insights from genome-wide analyses of protein-protein interactions. Curr. Opin. Struct. Biol. 50: 42-48 (2018).
  4. Widespread expansion of protein interaction capabilities by alternative splicing. Cell 164: 805-817 (2016).
  5. Widespread macromolecular interaction perturbations in human genetic disorders. Cell 161: 647-660 (2015).
  6. Structural principles within the human-virus protein-protein interaction network. Proc. Natl. Acad. Sci. USA 108: 10538-10543 (2011).
  7. Structural determinants of protein evolution are context-sensitive at the residue level. Mol. Biol. Evol. 26: 2387-2395 (2009).
  8. Relating three-dimensional structures to protein networks provides evolutionary insights. Science 314: 1938-1941 (2006).
  9. Roles of mutation and recombination in the evolution of protein thermodynamics. Proc. Natl. Acad. Sci. USA 99: 10382-10387 (2002).
  10. Ab initio construction of protein tertiary structures using a hierarchical approach. J. Mol. Biol. 300: 171-185 (2000).
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Yu (Brandon) Xia Lab  |  Department of Bioengineering  |  McGill University