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Yu (Brandon) Xia

Department of Bioengineering
McGill University
3480 University Street
Montreal, Quebec H3A 0E9, Canada

Office: McConnell Engineering Building, Room 360
Phone: 514-398-5026 (O), 514-246-8751 (C)


I am a Professor of Bioengineering at McGill University, where I hold the Canada Research Chair in Computational and Systems Biology. At McGill, I am also affiliated with the Graduate Program in Biological and Biomedical Engineering, the Graduate Program in Quantitative Life Sciences, the Quantitative Biology Initiative, the Centre for Structural Biology, and the Department of Biomedical Engineering. External to McGill, I am affiliated with the Center for Cancer Systems Biology at Dana-Farber Cancer Institute, and the Bioinformatics Program at Boston University.

I graduated from Peking University with B.S. in Chemistry (major) and Computer Science (minor). I received my Ph.D. in Chemistry from Stanford University, specializing in computational structural biology with Michael Levitt (2013 Nobel laureate). After postdoctoral research with Mark Gerstein at Yale University, I became an Assistant Professor of Bioinformatics and Chemistry at Boston University. I joined McGill University in 2013 as an Associate Professor, where I was subsequently promoted to Professor.

Here is my Google Scholar profile.


  1. Nature of long-range evolutionary constraint in enzymes: insights from comparison to pseudoenzymes with similar structures. Mol. Biol. Evol., in press.
  2. Interactome evolution: insights from genome-wide analyses of protein-protein interactions. Curr. Opin. Struct. Biol. 50: 42-48 (2018).
  3. Domain-based prediction of the human isoform interactome provides insights into the functional impact of alternative splicing. PLoS Comput. Biol. 13: e1005717 (2017).
  4. The impact of native state switching on protein sequence evolution. Mol. Biol. Evol. 34: 1378-1390 (2017).
  5. Widespread expansion of protein interaction capabilities by alternative splicing. Cell 164: 805-817 (2016).
  6. Widespread macromolecular interaction perturbations in human genetic disorders. Cell 161: 647-660 (2015).
  7. Signatures of pleiotropy, economy and convergent evolution in a domain-resolved map of human-virus protein-protein interaction networks. PLoS Pathog. 9: e1003778 (2013).
  8. Structural principles within the human-virus protein-protein interaction network. Proc. Natl. Acad. Sci. USA 108: 10538-10543 (2011).
  9. Predicting eukaryotic transcriptional cooperativity by Bayesian network integration of genome-wide data. Nucleic Acids Res. 37: 5943-5958 (2009).
  10. Structural determinants of protein evolution are context-sensitive at the residue level. Mol. Biol. Evol. 26: 2387-2395 (2009).
  11. Relating three-dimensional structures to protein networks provides evolutionary insights. Science 314: 1938-1941 (2006).
  12. Simulating potein evolution in sequence and structure space. Curr. Opin. Struct. Biol. 14: 202-207 (2004).
  13. Roles of mutation and recombination in the evolution of protein thermodynamics. Proc. Natl. Acad. Sci. USA 99: 10382-10387 (2002).
  14. Ab initio construction of protein tertiary structures using a hierarchical approach. J. Mol. Biol. 300: 171-185 (2000).

Yu (Brandon) Xia Lab  |  Department of Bioengineering  |  McGill University