Yu (Brandon) Xia
Department of Bioengineering
3480 University Street
Montreal, Quebec H3A 0E9, Canada
Office: McConnell Engineering Building, Room 360
I am a Professor in the Department of Bioengineering at McGill
University, where I hold the Canada Research
Chair in Computational and
Systems Biology. At McGill, I am also affiliated with the Graduate Program in Biological and Biomedical
Engineering, the Graduate Program in Quantitative Life Sciences, the Centre de Recherche en Biologie Structurale, the Centre for Applied Mathematics in Bioscience and Medicine, and the Department of Biomedical Engineering.
External to McGill, I am affiliated with the Center for Cancer Systems Biology
at Dana-Farber Cancer Institute.
I graduated from Peking University in 1995 with B.S. in Chemistry (major) and
Computer Science (minor). I received my Ph.D. in Chemistry from Stanford
University in 2003, specializing in computational biology with Michael Levitt. After postdoctoral research with Mark Gerstein at Yale
University, I became an
Assistant Professor of Bioinformatics and Chemistry at Boston University, with a secondary appointment in Biomedical Engineering.
I joined McGill University
in 2013 as Associate Professor and was promoted to Professor in 2018. My
research interests include: computational
biology, structural bioinformatics, biological networks, and evolution.
Honors and awards include:
Gold Medal, International Chemistry Olympiad (1990),
Howard Hughes Medical Institute Predoctoral Fellowship (1996),
Jane Coffin Childs Fellowship (2004),
PhRMA Foundation Research Starter Grant in Informatics (2008),
K. C. Wong Research Award (2010),
Tier 1 Canada Research Chair (2015, 2022),
NSERC Discovery Accelerator Supplement Award (2019).
Explore my Google Scholar profile,
and academic genealogy.
- Are transient protein-protein
interactions more dispensable? PLOS Comput. Biol. 18: e1010013
- Quantifying evolutionary importance of protein sites: a tale of two measures. PLOS Genet. 17: e1009476 (2021).
- Estimating dispensable content in the human interactome. Nat. Commun. 10: 3205 (2019).
- Nature of long-range evolutionary constraint in enzymes: insights from comparison to pseudoenzymes with similar
structures. Mol. Biol. Evol. 35: 2597-2606 (2018).
- Interactome evolution: insights from genome-wide analyses of protein-protein
interactions. Curr. Opin. Struct. Biol. 50: 42-48 (2018).
prediction of the human
isoform interactome provides insights into the functional impact of alternative splicing. PLOS Comput. Biol.
13: e1005717 (2017).
- Widespread expansion of protein interaction capabilities by alternative splicing.
Cell 164: 805-817 (2016).
- Widespread macromolecular
interaction perturbations in human genetic disorders.
Cell 161: 647-660 (2015).
- Signatures of pleiotropy, economy and
convergent evolution in a domain-resolved map of human-virus
protein-protein interaction networks. PLOS Pathog. 9: e1003778 (2013).
Structural principles within the human-virus protein-protein interaction network.
Proc. Natl. Acad. Sci. USA 108: 10538-10543 (2011).
Structural determinants of protein evolution are context-sensitive at the residue level.
Mol. Biol. Evol. 26: 2387-2395 (2009).
Relating three-dimensional structures to protein networks provides evolutionary insights.
Science 314: 1938-1941 (2006).
- Roles of mutation and recombination in the evolution of protein thermodynamics. Proc. Natl. Acad. Sci. USA 99: 10382-10387 (2002).
- Ab initio construction of protein tertiary structures using a hierarchical approach. J. Mol. Biol. 300: 171-185 (2000).